Invention Grant
US07989424B2 Glucopyranosyloxypyrazole derivatives and use thereof in medicines
有权
吡喃葡萄糖氧吡唑衍生物及其在药物中的应用
- Patent Title: Glucopyranosyloxypyrazole derivatives and use thereof in medicines
- Patent Title (中): 吡喃葡萄糖氧吡唑衍生物及其在药物中的应用
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Application No.: US12169882Application Date: 2008-07-09
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Publication No.: US07989424B2Publication Date: 2011-08-02
- Inventor: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- Applicant: Hideki Fujikura , Nobuhiko Fushimi , Toshihiro Nishimura , Takeshi Nakabayashi , Masayuki Isaji
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Sughrue Mion, PLLC
- Priority: JP2000-403534 20001228
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70

Abstract:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
Public/Granted literature
- US20090093419A1 GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES Public/Granted day:2009-04-09
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