Invention Grant
- Patent Title: LNA antagonists targeting the androgen receptor
- Patent Title (中): 靶向雄激素受体的LNA拮抗剂
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Application No.: US12726554Application Date: 2010-03-18
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Publication No.: US07989429B2Publication Date: 2011-08-02
- Inventor: Jesper Worm
- Applicant: Jesper Worm
- Applicant Address: US NJ Bridgewater DK Hoersholm
- Assignee: Enzon Pharmaceuticals, Inc.,Santaris Pharma A/S
- Current Assignee: Enzon Pharmaceuticals, Inc.,Santaris Pharma A/S
- Current Assignee Address: US NJ Bridgewater DK Hoersholm
- Agency: Lucas & Mercanti, LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04
Abstract:
The invention relates to oligonucleotide compounds (oligomers), which target androgen receptor mRNA in a cell, leading to reduced expression of the androgen receptor. Reduction of the androgen receptor expression is beneficial for the treatment of certain disorders, such as a hyperproliferative disorders (e.g., cancer). The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of androgen receptor using said oligomers, including methods of treatment.
Public/Granted literature
- US20100234451A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR Public/Granted day:2010-09-16
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