Invention Grant
- Patent Title: 4,5-dihydro-oxazol-2-yl amine derivatives
- Patent Title (中): 4,5-二氢 - 恶唑-2-基胺衍生物
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Application No.: US12369782Application Date: 2009-02-12
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Publication No.: US07989449B2Publication Date: 2011-08-02
- Inventor: Matteo Andreini , Emanuele Gabellieri , Wolfgang Guba , Guido Marconi , Robert Narquizian , Eoin Power , Massimiliano Travagli , Thomas Woltering , Wolfgang Wostl
- Applicant: Matteo Andreini , Emanuele Gabellieri , Wolfgang Guba , Guido Marconi , Robert Narquizian , Eoin Power , Massimiliano Travagli , Thomas Woltering , Wolfgang Wostl
- Applicant Address: US NJ Nutley IT Siena
- Assignee: Hoffman-La Roche Inc.,Siena Biotech S.p.A.
- Current Assignee: Hoffman-La Roche Inc.,Siena Biotech S.p.A.
- Current Assignee Address: US NJ Nutley IT Siena
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP08151546 20080218
- Main IPC: A61K31/421
- IPC: A61K31/421 ; A61K31/506 ; A61K31/4439 ; A61K31/538 ; C07D263/28 ; C07D413/10
Abstract:
The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceutically active acid addition salts thereof. Compounds of the invention have Asp2 (β-secretase, BACE 1 or Memapsin-2) inhibitory activity and are useful for the treatment of diseases characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
Public/Granted literature
- US20090209529A1 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES Public/Granted day:2009-08-20
Information query
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