Invention Grant
- Patent Title: mGluR1 antagonists as therapeutic agents
- Patent Title (中): mGluR1拮抗剂作为治疗药
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Application No.: US12356867Application Date: 2009-01-21
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Publication No.: US07989464B2Publication Date: 2011-08-02
- Inventor: Julius J. Matasi , Deen Tulshian , Duane A. Burnett , Wen-Lian Wu , Peter Korakas , Lisa S. Silverman , Thavalakulamgara K. Sasikumar , Li Qiang , Martin S. Domalski
- Applicant: Julius J. Matasi , Deen Tulshian , Duane A. Burnett , Wen-Lian Wu , Peter Korakas , Lisa S. Silverman , Thavalakulamgara K. Sasikumar , Li Qiang , Martin S. Domalski
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Agent Kenrick L. Vidale; Keith D. MacMillan; John C. Todaro
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D239/00 ; C07D471/00 ; C07D487/00

Abstract:
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
Public/Granted literature
- US20090192178A1 mGluR1 ANTAGONISTS AS THERAPEUTIC AGENTS Public/Granted day:2009-07-30
Information query
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