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US07989532B2 RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β tricalcium phosphate composite material and preparation method thereof 有权
RGD多肽接枝的聚（乙醇酸-L-赖氨酸-L-乳酸）/ bgr; 磷酸三钙复合材料及其制备方法

RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β tricalcium phosphate composite material and preparation method thereof
Abstract:
An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid)/β-tricalcium phosphate composite material is composed of β-tricalcium phosphate particles and RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass ratio of 1:10-1:100, in which the β-tricalcium phosphate particles are uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) matrix. The preparation method includes that poly (glycolic acid-L-lysine-L-lactic acid) is polymerized with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence) to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid), and then RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) is compounded with β-tricalcium phosphate particles. The composite material exhibits favorable biocompatibility, cellular affinity, biodegradability and mechanical behavior, and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous bone scaffold for repairing nerve tissue and bone tissue.
Abstract(Chinese):

RGD多肽接枝的聚（乙醇酸-L-赖氨酸-L-乳酸）/磷酸三钙复合材料由磷酸三钙颗粒和RGD多肽接枝的聚（乙醇酸-L-赖氨酸-L- 乳酸），质量比为1：10-1：100，其中磷酸三钙颗粒均匀分散在RGD多肽接枝的聚（乙醇酸-L-赖氨酸-L-乳酸）基质中。 制备方法包括聚（乙醇酸-L-赖氨酸-L-乳酸）与GRGDY短肽（甘氨酸 - 精氨酸 - 甘氨酸 - 天冬氨酸 - 酪氨酸序列）聚合，得到RGD多肽接枝的聚（乙醇酸-L-乳酸） 赖氨酸-L-乳酸），然后将RGD多肽接枝的聚（乙醇酸-L-赖氨酸-L-乳酸）与磷酸二钙颗粒复合。 复合材料表现出良好的生物相容性，细胞亲和力，生物降解性和机械性能，可以避免组织的无菌性坏死，可用作修复神经组织和骨组织的神经导管或多孔骨架。

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