Invention Grant
- Patent Title: Cell permeable peptide
- Patent Title (中): 细胞可渗透肽
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Application No.: US11883810Application Date: 2006-02-09
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Publication No.: US07989588B2Publication Date: 2011-08-02
- Inventor: Shinsaku Nakagawa , Tadanori Mayumi , Kiichi Fukui
- Applicant: Shinsaku Nakagawa , Tadanori Mayumi , Kiichi Fukui
- Applicant Address: JP Osaka JP Osaka
- Assignee: Osaka University,Nitto Denko Corporation
- Current Assignee: Osaka University,Nitto Denko Corporation
- Current Assignee Address: JP Osaka JP Osaka
- Agency: Fitch, Even, Tabin & Flannery
- Priority: JP2005-035290 20050210
- International Application: PCT/JP2006/302255 WO 20060209
- International Announcement: WO2006/085583 WO 20060817
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K19/00 ; A61K47/48

Abstract:
The number of peptides having an ability to bind to a cell or penetrate into a cell is narrowed down by being selectively enriched from a random peptide library with a diversity of not less than one hundred millions of peptides using a phage surface display technique, and then cytoplasmic transfer is evaluated by using protein synthesis inhibition as an indicator by adding to a cell, a fusion body of the selectively enriched peptide and a protein synthesis inhibitory factor (PSIF) that cannot solely penetrate into the cell.
Public/Granted literature
- US20110045009A1 Cell Permeable Peptide Public/Granted day:2011-02-24
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