Invention Grant
- Patent Title: Aryl spirolactam CGRP receptor antagonists
- Patent Title (中): 芳基己内酰胺CGRP受体拮抗剂
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Application No.: US11662424Application Date: 2005-09-06
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Publication No.: US07989624B2Publication Date: 2011-08-02
- Inventor: Ian M. Bell , Craig A. Stump , Cory R. Theberge
- Applicant: Ian M. Bell , Craig A. Stump , Cory R. Theberge
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Raynard Yuro; Gerard M. Devlin
- International Application: PCT/US2005/031712 WO 20050906
- International Announcement: WO2006/031513 WO 20060323
- Main IPC: A61K31/438
- IPC: A61K31/438 ; C07D401/14 ; C07D209/54 ; C07D209/04
Abstract:
The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5b, R5c and X are as defined herein useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20080004304A1 Aryl Spirolactam Cgrp Receptor Antagonists Public/Granted day:2008-01-03
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