Invention Grant
- Patent Title: Process for preparation of citalopram and enantiomers
- Patent Title (中): 西酞普兰和对映异构体的制备方法
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Application No.: US12024492Application Date: 2008-02-01
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Publication No.: US07989645B2Publication Date: 2011-08-02
- Inventor: Periyandi Nagarajan , Kilaru Srinivasu , Thennati Rajamannar
- Applicant: Periyandi Nagarajan , Kilaru Srinivasu , Thennati Rajamannar
- Applicant Address: AE Sharjah
- Assignee: Sun Pharma Global FZE
- Current Assignee: Sun Pharma Global FZE
- Current Assignee Address: AE Sharjah
- Agency: Sughrue Mion, PLLC
- Priority: IN912/MUM/2004 20040823
- Main IPC: C07D307/87
- IPC: C07D307/87

Abstract:
The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran car-bonitrile comprising reacting a compound of formula IVa, in the presence of a base with a compound of formula RX, wherein R is selected from alkyl, alkenyl, aryl and heteroaryl which may be optionally substituted with electron withdrawing groups and X is selected from F, Cl, Br, I, CN, OTf and OR1, wherein Tf represents trifluoromethanesulfonyl group, and R1 is optionally substituted alkyl, Z is a cyano group or a group that may be converted to a cyano group; further wherein RX is selected such that an intermediate ether derivative, a compound of formula Va formed from said reaction cyclizes to a compound of formula VI, and where Z is not a cyano group, conversion of the group Z in the compound of formula VI to a cyano group to form 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile. The present invention also provides novel ether compound, a compound of formula Va and a process for preparation thereof.
Public/Granted literature
- US20080177096A1 PROCESS FOR PREPARATION OF CITALOPRAM AND ENANTIOMERS Public/Granted day:2008-07-24
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