Invention Grant
- Patent Title: Human ADAM-10 inhibitors
- Patent Title (中): 人ADAM-10抑制剂
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Application No.: US12605118Application Date: 2009-10-23
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Publication No.: US07989661B2Publication Date: 2011-08-02
- Inventor: Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
- Applicant: Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
- Applicant Address: US MD Rockville
- Assignee: Symphony Evolution, Inc.
- Current Assignee: Symphony Evolution, Inc.
- Current Assignee Address: US MD Rockville
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C07C309/09
- IPC: C07C309/09
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
Public/Granted literature
- US20100105953A1 Human Adam-10 Inhibitors Public/Granted day:2010-04-29
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