An image pickup device having an electron multiplying-charge coupled device includes a control unit for controlling an electron multiplication factor of the electron multiplying-charge coupled device; an obtaining unit for obtaining signals output from predetermined pixels of the electron multiplying-charge coupled device; and an averaging unit for performing an inter-line averaging process of the signals obtained by the obtaining unit. The device further includes a suppression unit for performing low-level and high-level suppressions on the signal averaged by the averaging unit based on the electron multiplication factor of the electron multiplication factor control unit; an acquisition unit for acquiring image signals output from the pixels other than the predetermined pixels of the electron multiplying-charge coupled device; and a subtractor for subtracting the signal suppressed by the suppression unit from the image signals acquired by the acquisition unit.