Methods and apparatus to bound network traffic estimation error for multistage measurement sampling and aggregation are disclosed. An example method disclosed herein comprises determining a hierarchical sampling topology representative of multiple data sampling and aggregation stages, the hierarchical sampling topology comprising a plurality of nodes connected by a plurality of edges, each node corresponding to at least one of a data source and a data aggregation operation, and each edge corresponding to a data sampling operation characterized by a generalized sampling threshold, selecting a first generalized sampling threshold from a set of generalized sampling thresholds associated with a respective set of edges originating at a respective set of descendent nodes of a target node undergoing network traffic estimation, and transforming a measured sample of network traffic into a confidence interval for a network traffic estimate associated with the target node using the first generalized sampling threshold and an error parameter.