A retransmission method and apparatus in a multi-hop broadband wireless communication system are provided, in which if there is a failed data block among data blocks received from a source node, a Relay Station (RS) transmits a feedback message requesting retransmission of the failed data block to the source node, transmits a successfully received data block to a destination node, receives a retransmitted data block for the failed data block from the source node, transmits the received retransmitted data block to the destination node, receives from the destination node a feedback message about data blocks transmitted to the destination node, and transmits the feedback message to the source node.