Method and apparatus for communication between a processor and processing elements in an integrated circuit (e.g., a programmable logic device is described. In an example, a first lookup table is configured to store first information representing which of the processing elements is capable of performing which of a plurality of instructions. A second lookup table is configured to store second information representing which of the plurality of instructions is being serviced by which of the processing elements. Control logic is coupled to the processor, the first lookup table, and the second lookup table. The control logic is configured to communicate data from the processor to the processing elements based on the first information, and communicate data from the processing elements to the processor based on the second information.