A method for operating a brake system of a motor vehicle, which has at least one operating mode (normal, sporty, etc.), includes prefilling, to at least partially overcome a clearance of one or a plurality of wheel brake(s) prior to an expected actuation of a brake pedal, an actuation of the brake pedal being expected at specific positions and/or gradients of the actuation of operating devices of the motor vehicle, in particular an accelerator pedal. The method includes an operating mode in which the gradient is specified as a function of the dynamics and/or limit values of the actuation of the operating devices.