An endoscopic wire guide apparatus for insertion through an insertion tube of an endoscope having an accessory port, the endoscope being configured for advancement into a patient. The apparatus comprises a wire guide disposed through the insertion tube for delivery into the patient. The wire guide has a distal portion and a proximal portion. The distal portion has a first diameter and the proximal portion has a second diameter less than the first diameter. The first diameter is more rigid than the second diameter. The second diameter is configured to allow the proximal portion to collapse when proximally extending through the accessory port of the endoscope and the distal portion extends at least partially beyond the distal end of the insertion tube.