Invention Grant
US07993627B2 Methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal
失效
用于确定化合物是否改变至少一种α和bgr的量的方法; （X-41）肽和总α和bgr的量; 或至少一个α＆bgr; （X-40）肽
- Patent Title: Methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal
- Patent Title (中): 用于确定化合物是否改变至少一种α和bgr的量的方法; （X-41）肽和总α和bgr的量; 或至少一个α＆bgr; （X-40）肽
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Application No.: US10335035Application Date: 2002-12-30
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Publication No.: US07993627B2Publication Date: 2011-08-09
- Inventor: Martin Citron , Dennis J. Selkoe , Peter A. Seubert , Dale B. Schenk
- Applicant: Martin Citron , Dennis J. Selkoe , Peter A. Seubert , Dale B. Schenk
- Applicant Address: US CA South San Francisco US MA Boston
- Assignee: Elan Pharmaceuticals, Inc.,Brigham and Women's Hospital
- Current Assignee: Elan Pharmaceuticals, Inc.,Brigham and Women's Hospital
- Current Assignee Address: US CA South San Francisco US MA Boston
- Agency: Alston and Bird LLP
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≧41) alone or in combination with Aβ(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ(x≦40) and Aβ(x≧41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.
Public/Granted literature
- US20030148392A1 Screening compounds for the ability to alter the production of amyloid-beta peptide (x-41) Public/Granted day:2003-08-07
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