Invention Grant
- Patent Title: Menthol-containing formulation
- Patent Title (中): 含薄荷醇的配方
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Application No.: US12458876Application Date: 2009-07-27
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Publication No.: US07993635B2Publication Date: 2011-08-09
- Inventor: Tomonori Hamawaki , Yosuke Kataoka , Takako Isoda
- Applicant: Tomonori Hamawaki , Yosuke Kataoka , Takako Isoda
- Applicant Address: JP Tokyo
- Assignee: Nihon Pharamaceutical Co., Ltd.
- Current Assignee: Nihon Pharamaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2003-186493 20030630
- Main IPC: A61K9/107
- IPC: A61K9/107

Abstract:
It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100 nm.Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.
Public/Granted literature
- US20090292028A1 Menthol-containing formulation Public/Granted day:2009-11-26
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