Invention Grant
- Patent Title: Anti-MPL antibodies
- Patent Title (中): 抗MPL抗体
-
Application No.: US10551504Application Date: 2004-12-10
-
Publication No.: US07993642B2Publication Date: 2011-08-09
- Inventor: Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
- Applicant: Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2003-415746 20031212; JP2004-071763 20040312; JP2004-248323 20040827
- International Application: PCT/JP2004/018506 WO 20041210
- International Announcement: WO2005/056604 WO 20050623
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08 ; C07K16/00
Abstract:
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
Public/Granted literature
- US20060222643A1 Anti-mpl antibody Public/Granted day:2006-10-05
Information query
