Invention Grant
US07993648B2 Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody
有权
免疫刺激方案包括施用1型干扰素和激动性抗CD40抗体
- Patent Title: Immunostimulatory regimen comprising administering type 1 interferon and agonistic anti-CD40 antibody
- Patent Title (中): 免疫刺激方案包括施用1型干扰素和激动性抗CD40抗体
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Application No.: US11743978Application Date: 2007-05-03
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Publication No.: US07993648B2Publication Date: 2011-08-09
- Inventor: Ross Kedl , Phillip J. Sanchez , Catherine Haluszczak
- Applicant: Ross Kedl , Phillip J. Sanchez , Catherine Haluszczak
- Applicant Address: US CO Denver
- Assignee: The Regents of the Universitry of Colorado
- Current Assignee: The Regents of the Universitry of Colorado
- Current Assignee Address: US CO Denver
- Agency: Hunton & Williams LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K38/19 ; A61K38/21
Abstract:
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
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