Invention Grant
US07993651B2 Chimeric human immunodeficiency virus (HIV) immunogens comprising GAG P24-P17 fused to multiple cytotoxic T lymphocyte (CTL) epitopes
失效
包含与多种细胞毒性T淋巴细胞（CTL）表位融合的GAG P24-P17的嵌合人免疫缺陷病毒（HIV）免疫原
- Patent Title: Chimeric human immunodeficiency virus (HIV) immunogens comprising GAG P24-P17 fused to multiple cytotoxic T lymphocyte (CTL) epitopes
- Patent Title (中): 包含与多种细胞毒性T淋巴细胞（CTL）表位融合的GAG P24-P17的嵌合人免疫缺陷病毒（HIV）免疫原
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Application No.: US10168843Application Date: 2000-12-22
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Publication No.: US07993651B2Publication Date: 2011-08-09
- Inventor: Tomas Hanke , Andrew McMichael
- Applicant: Tomas Hanke , Andrew McMichael
- Applicant Address: GB London US NY New York KE Nairobi
- Assignee: Medical Research Council,International AIDS Vaccine Initiative,University of Nairobi
- Current Assignee: Medical Research Council,International AIDS Vaccine Initiative,University of Nairobi
- Current Assignee Address: GB London US NY New York KE Nairobi
- Agency: Vedder Price P.C.
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: GB9930294.5 19991223; GB0025234.6 20001014
- International Application: PCT/GB00/04984 WO 20001222
- International Announcement: WO01/47955 WO 20010705
- Main IPC: A61K39/21
- IPC: A61K39/21
Abstract:
Disclosed is an immunogen in sterile form suitable for administration to a human subject, the immunogen comprising: at least a portion of the gag protein of HIV, said gag protein being from an HIV clade or having a consensus sequence for one or more HIV clades, and comprising at least parts of p17 and p24; and a synthetic polypeptide comprising a plurality of amino acid sequences, each sequence comprising a human CTL epitope of an HIV protein, and wherein a plurality of HIV proteins are represented in the synthetic polypeptide, said CTL epitopes being selected to stimulate an immune response to one or more HIV clades of interest.
Public/Granted literature
- US20030108562A1 Immune responses to hiv Public/Granted day:2003-06-12
Information query
