Invention Grant
US07993824B2 Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors
有权
用于确定致病病毒对蛋白酶抑制剂的敏感性的组合物和方法
- Patent Title: Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors
- Patent Title (中): 用于确定致病病毒对蛋白酶抑制剂的敏感性的组合物和方法
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Application No.: US10612603Application Date: 2003-07-01
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Publication No.: US07993824B2Publication Date: 2011-08-09
- Inventor: Colombe Chappey , Christos J. Petropoulos , Neil T. Parkin
- Applicant: Colombe Chappey , Christos J. Petropoulos , Neil T. Parkin
- Applicant Address: US CA South San Francisco
- Assignee: Monogram Biosciences, Inc.
- Current Assignee: Monogram Biosciences, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Kilpatrick, Townsend & Stockton
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; C12Q1/68 ; G01N33/00
Abstract:
The present invention provides an approach for developing an algorithm for determining the effectiveness of anti-viral drugs based on a comprehensive analysis of paired phenotypic and genotypic data guided by phenotypic clinical cut-offs. In one aspect, the algorithm allows one to provide a patient with effective treatment. It helps predict whether an infected individual will respond to treatment with an anti-viral compound, thereby allowing an effective treatment regimen to be designed without subjecting the patient to unnecessary side effects. Also, by avoiding the administration of ineffective drugs, considerable time and money is saved.
Public/Granted literature
- US20040248084A1 Compositions and methods for determining the susceptibility of a pathogenic virus to protease inhibitors Public/Granted day:2004-12-09
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