Invention Grant
US07993834B2 Detection of ErbB2 gene amplification to increase the likelihood of the effectiveness of ErbB2 antibody breast cancer therapy
有权
检测ErbB2基因扩增增加ErbB2抗体乳腺癌治疗有效性的可能性
- Patent Title: Detection of ErbB2 gene amplification to increase the likelihood of the effectiveness of ErbB2 antibody breast cancer therapy
- Patent Title (中): 检测ErbB2基因扩增增加ErbB2抗体乳腺癌治疗有效性的可能性
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Application No.: US11942449Application Date: 2007-11-19
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Publication No.: US07993834B2Publication Date: 2011-08-09
- Inventor: Robert D. Mass
- Applicant: Robert D. Mass
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Diane Marschang; Ginger R. Dreger
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/574
Abstract:
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing ErbB, as determined by a gene amplification assay, with an ErbB antagonist. Such method comprises administering a cancer-treating dose of the ErbB antagonist, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells ErbB has been found to be amplified e.g., by fluorescent in situ hybridization. ErbB antagonists described include an anti-HER2 antibody. Pharmaceutical packaging for providing the components for such treatment is also provided.
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