Invention Grant
US07993924B2 cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses
有权
对应于非分段负链RNA病毒的反向单元的cDNA和用于产生这种病毒的方法
- Patent Title: cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses
- Patent Title (中): 对应于非分段负链RNA病毒的反向单元的cDNA和用于产生这种病毒的方法
-
Application No.: US11899492Application Date: 2007-09-06
-
Publication No.: US07993924B2Publication Date: 2011-08-09
- Inventor: Martin A. Billeter , Pius Spielhofer , Karin Kälin , Frank Radecke , Henriette Schneider
- Applicant: Martin A. Billeter , Pius Spielhofer , Karin Kälin , Frank Radecke , Henriette Schneider
- Applicant Address: CH Bern
- Assignee: Crucell Switzerland AG
- Current Assignee: Crucell Switzerland AG
- Current Assignee Address: CH Bern
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: EP95112559 19950809
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A01N65/00 ; A61K39/12 ; A61K39/155 ; A61K39/165 ; A61K48/00 ; C12N15/00
Abstract:
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
Public/Granted literature
Information query
