Invention Grant
- Patent Title: Micro-RNAs that modulate smooth muscle proliferation and differentiation and uses thereof
- Patent Title (中): 调节平滑肌增殖和分化的微RNA和其用途
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Application No.: US12391028Application Date: 2009-02-23
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Publication No.: US07994150B2Publication Date: 2011-08-09
- Inventor: Eric Olson , Eric Small , Mei Xin
- Applicant: Eric Olson , Eric Small , Mei Xin
- Applicant Address: US TX Austin
- Assignee: Board of Regents, the University of Texas System
- Current Assignee: Board of Regents, the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Cooley LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00
Abstract:
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed.
Public/Granted literature
- US20090226375A1 MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF Public/Granted day:2009-09-10
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