Invention Grant
- Patent Title: c-Kit kinase inhibitor
- Patent Title (中): c-Kit激酶抑制剂
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Application No.: US10797903Application Date: 2004-03-10
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Publication No.: US07994159B2Publication Date: 2011-08-09
- Inventor: Yuji Yamamoto , Tatsuo Watanabe , Masayuki Okada , Akihiko Tsuruoka
- Applicant: Yuji Yamamoto , Tatsuo Watanabe , Masayuki Okada , Akihiko Tsuruoka
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JPP2003-062823 20030310; JPP2003-302803 20030827
- Main IPC: A61K31/33
- IPC: A61K31/33 ; A01N43/00

Abstract:
It was discovered that a compound represented by the general formula (I) shows strong c-Kit kinase inhibitory activity, and it inhibits proliferation of c-Kit kinase activated-cancer cells in vitro and in vivo. A novel anticancer agent showing c-Kit kinase inhibitory activity was discovered.The general formula (I): (wherein R1 represents methyl etc., R2 represents cyano etc., R3 represents hydrogen etc., R4 represents hydrogen etc.).
Public/Granted literature
- US20040253205A1 c-Kit kinase inhibitor Public/Granted day:2004-12-16
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