Invention Grant
- Patent Title: Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11-β-羟基类固醇脱氢酶抑制剂1
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Application No.: US12297964Application Date: 2007-04-24
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Publication No.: US07994176B2Publication Date: 2011-08-09
- Inventor: Renhua Li , Thomas Edward Mabry , Owen Brendan Wallace , Leonard Larry Winneroski, Jr. , Yanping Xu
- Applicant: Renhua Li , Thomas Edward Mabry , Owen Brendan Wallace , Leonard Larry Winneroski, Jr. , Yanping Xu
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2007/067296 WO 20070424
- International Announcement: WO2007/127726 WO 20071108
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/454 ; C07D403/02 ; C07D401/14 ; C07D401/04 ; C07D207/26
Abstract:
The present invention discloses novel compounds of Formula I: having 11 Beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11 Beta-HSD type 1 activity. X-17377
Public/Granted literature
- US20090099182A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2009-04-16
Information query
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