Invention Grant
US07994181B2 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
有权
6-1H-咪唑并喹唑啉和喹啉衍生物，新型强效止痛剂和抗炎剂
- Patent Title: 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents
- Patent Title (中): 6-1H-咪唑并喹唑啉和喹啉衍生物，新型强效止痛剂和抗炎剂
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Application No.: US12376080Application Date: 2006-08-03
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Publication No.: US07994181B2Publication Date: 2011-08-09
- Inventor: Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
- Applicant: Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
- Applicant Address: IT Milan
- Assignee: Rottapharm S.p.A.
- Current Assignee: Rottapharm S.p.A.
- Current Assignee Address: IT Milan
- Agency: Sughrue Mion, PLLC
- International Application: PCT/EP2006/065013 WO 20060803
- International Announcement: WO2008/014822 WO 20080207
- Main IPC: A61K31/517
- IPC: A61K31/517
Abstract:
The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases.Formula I:
Public/Granted literature
- US20090264451A1 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS Public/Granted day:2009-10-22
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