Invention Grant
US07994182B2 Quinazolinone-derivatives and their use for preparation of pharmaceutical compositions having PARP enzyme inhibitory effect
有权
喹唑啉酮衍生物及其用于制备具有PARP酶抑制作用的药物组合物的用途
- Patent Title: Quinazolinone-derivatives and their use for preparation of pharmaceutical compositions having PARP enzyme inhibitory effect
- Patent Title (中): 喹唑啉酮衍生物及其用于制备具有PARP酶抑制作用的药物组合物的用途
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Application No.: US10554749Application Date: 2004-04-30
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Publication No.: US07994182B2Publication Date: 2011-08-09
- Inventor: Balázs Sümegi , Kálmán Hideg , Tamás Kálai
- Applicant: Balázs Sümegi , Kálmán Hideg , Tamás Kálai
- Applicant Address: HU Pecs
- Assignee: Pecsi Tudomanyegyetem
- Current Assignee: Pecsi Tudomanyegyetem
- Current Assignee Address: HU Pecs
- Agency: Young & Thompson
- Priority: HU0301173 20030430
- International Application: PCT/HU2004/000044 WO 20040430
- International Announcement: WO2004/096779 WO 20041111
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/88 ; C07D403/12
Abstract:
The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.
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