Invention Grant
US07994183B2 Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
有权
包含2 - [[6 - [（3R）-3-氨基-1-哌啶基] -3,4-二氢-3-甲基-2,4-二氧代-1（2H） - 嘧啶基]甲基] -4 - 氟苄腈
![Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile](/docs/US/2011-08-09/US07994183B2/abs.jpg.600x600.jpg)
- Patent Title: Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile
- Patent Title (中): 包含2 - [[6 - [（3R）-3-氨基-1-哌啶基] -3,4-二氢-3-甲基-2,4-二氧代-1（2H） - 嘧啶基]甲基] -4 - 氟苄腈
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Application No.: US12450118Application Date: 2008-03-12
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Publication No.: US07994183B2Publication Date: 2011-08-09
- Inventor: Yusuke Murakawa , Miyuki Hohokabe
- Applicant: Yusuke Murakawa , Miyuki Hohokabe
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Foley & Lardner LLP
- Priority: JP2007-064245 20070313
- International Application: PCT/JP2008/055016 WO 20080312
- International Announcement: WO2008/114800 WO 20080925
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D239/02
![Solid preparation comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile](/abs-image/US/2011/08/09/US07994183B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a solid preparation containing 2[[6-[(3R)-3-amino-1 -piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile (compound (A)) or a salt thereof as a pharmaceutically active ingredient. Specifically, the present invention provides a solid preparation containing a granule composed of compound (A) or a salt thereof and an additive (excluding microcrystalline cellulose) and a tablet containing (a) a granule containing compound (A) or a salt thereof and microcrystalline cellulose, and (b) a tableting aid containing magnesium stearate and microcrystalline cellulose.
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