Invention Grant
US07994207B2 Process for preparing fluoromethyl-substituted heterocyclic compounds 失效
氟甲基取代的杂环化合物的制备方法

  • Patent Title: Process for preparing fluoromethyl-substituted heterocyclic compounds
  • Patent Title (中): 氟甲基取代的杂环化合物的制备方法
  • Application No.: US12519032
    Application Date: 2007-12-20
  • Publication No.: US07994207B2
    Publication Date: 2011-08-09
  • Inventor: Thomas ZierkeMichael Rack
  • Applicant: Thomas ZierkeMichael Rack
  • Applicant Address: DE Ludwigshafen
  • Assignee: BASF SE
  • Current Assignee: BASF SE
  • Current Assignee Address: DE Ludwigshafen
  • Agency: Brinks Hofer Gilson & Lione
  • Priority: EP06126937 20061221
  • International Application: PCT/EP2007/064390 WO 20071220
  • International Announcement: WO2008/077907 WO 20080703
  • Main IPC: A61K31/415
  • IPC: A61K31/415 C07D231/12
Process for preparing fluoromethyl-substituted heterocyclic compounds
Abstract:
The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C2-C4-alkanediyl, R3 is C1-C4-alkyl and m is 1 or 2; by converting the corresponding chloromethyl-substituted compounds (II) in the presence of fluorinating agents, to processes for preparing the chloromethyl-substituted compounds (II), to processes for preparing amides of the general formula (IV) and to compounds of the general formulae (I) and (II).
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