Invention Grant
- Patent Title: Process for preparing fluoromethyl-substituted heterocyclic compounds
- Patent Title (中): 氟甲基取代的杂环化合物的制备方法
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Application No.: US12519032Application Date: 2007-12-20
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Publication No.: US07994207B2Publication Date: 2011-08-09
- Inventor: Thomas Zierke , Michael Rack
- Applicant: Thomas Zierke , Michael Rack
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Hofer Gilson & Lione
- Priority: EP06126937 20061221
- International Application: PCT/EP2007/064390 WO 20071220
- International Announcement: WO2008/077907 WO 20080703
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D231/12

Abstract:
The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C2-C4-alkanediyl, R3 is C1-C4-alkyl and m is 1 or 2; by converting the corresponding chloromethyl-substituted compounds (II) in the presence of fluorinating agents, to processes for preparing the chloromethyl-substituted compounds (II), to processes for preparing amides of the general formula (IV) and to compounds of the general formulae (I) and (II).
Public/Granted literature
- US20100022782A1 Process for Preparing Fluoromethyl-Substituted Heterocyclic Compounds Public/Granted day:2010-01-28
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