Invention Grant
US07994222B2 Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
失效
通过碘 - 硝基苯甲酰胺化合物监测脂肪酸合成的抑制
- Patent Title: Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
- Patent Title (中): 通过碘 - 硝基苯甲酰胺化合物监测脂肪酸合成的抑制
-
Application No.: US11850624Application Date: 2007-09-05
-
Publication No.: US07994222B2Publication Date: 2011-08-09
- Inventor: Valeria S. Ossovskaya , Barry M. Sherman
- Applicant: Valeria S. Ossovskaya , Barry M. Sherman
- Applicant Address: US CA South San Francisco
- Assignee: BiPar Sciences, Inc.
- Current Assignee: BiPar Sciences, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A61P3/04

Abstract:
The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
Public/Granted literature
- US20080103208A1 INHIBITION OF FATTY ACID SYNTHESIS BY PARP INHIBITORS AND METHODS OF TREATMENT THEREOF Public/Granted day:2008-05-01
Information query