Invention Grant
US07994305B2 Compositions and methods for siRNA inhibition of angiopoietin 1 and 2 and their receptor Tie2
有权
siRNA抑制血管生成素1和2及其受体Tie2的组合物和方法
- Patent Title: Compositions and methods for siRNA inhibition of angiopoietin 1 and 2 and their receptor Tie2
- Patent Title (中): siRNA抑制血管生成素1和2及其受体Tie2的组合物和方法
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Application No.: US10827759Application Date: 2004-04-19
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Publication No.: US07994305B2Publication Date: 2011-08-09
- Inventor: Samuel Jotham Reich , Michael J. Tolentino
- Applicant: Samuel Jotham Reich , Michael J. Tolentino
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pepper Hamilton LLP
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2 mediated angiogenesis, such as inflammatory and autoimmune diseases, diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Public/Granted literature
- US20040248174A1 Compositions and methods for siRNA inhibition of angiopoietin 1and 2 and their receptor Tie2 Public/Granted day:2004-12-09
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