Invention Grant
- Patent Title: Heterocycle-substituted benzimidazole derivative
- Patent Title (中): 杂环取代的苯并咪唑衍生物
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Application No.: US11988592Application Date: 2006-07-12
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Publication No.: US07994331B2Publication Date: 2011-08-09
- Inventor: Yoshio Ogino , Katsumasa Nonoshita , Teruyuki Nishimura , Jun-ichi Eiki
- Applicant: Yoshio Ogino , Katsumasa Nonoshita , Teruyuki Nishimura , Jun-ichi Eiki
- Applicant Address: JP
- Assignee: MSD K.K.
- Current Assignee: MSD K.K.
- Current Assignee Address: JP
- Agent Heidi M. Struse; Richard C. Billups
- Priority: JP2005-204438 20050713
- International Application: PCT/JP2006/314307 WO 20060712
- International Announcement: WO2007/007910 WO 20070118
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/44

Abstract:
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein X1 to X4 independently represent a carbon atom or the like; the ring A represents a 5- to 6-membered heteroaryl having 1 to 4 heteroatoms independently selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom; X5 represents an oxygen atom or the like; X represents a carbon atom or the like; Het represents a 5- or 6-membered aliphatic heterocycle; R1 represents an aryl or the like; R2 represents a formyl group or the like; and R3 represents a —C1-6 alkyl or the like. The compound or salt has a glucokinase activation effect and is useful as a therapeutic agent for diabetes.
Public/Granted literature
- US20100087360A1 Heterocycle-substituted benzimidazole derivative Public/Granted day:2010-04-08
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