Invention Grant
- Patent Title: Process for the production of amides
- Patent Title (中): 酰胺生产工艺
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Application No.: US12066683Application Date: 2006-09-14
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Publication No.: US07994341B2Publication Date: 2011-08-09
- Inventor: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
- Applicant: Hans Tobler , Harald Walter , Josef Ehrenfreund , Camilla Corsi , Fanny Giordano , Martin Zeller , Gottfried Seifert , Shailesh Shah , Neil George , Ian Kevin Jones , Paul Edward Bonnett
- Applicant Address: GB Guildford, Surrey
- Assignee: Syngenta Limited
- Current Assignee: Syngenta Limited
- Current Assignee Address: GB Guildford, Surrey
- Agent Rebecca Howard
- Priority: CH1520/05 20050916; CH0296/06 20060224
- International Application: PCT/EP2006/008982 WO 20060914
- International Announcement: WO2007/031323 WO 20070322
- Main IPC: C07D231/14
- IPC: C07D231/14

Abstract:
The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.
Public/Granted literature
- US20090163569A1 PROCESS FOR THE PRODUCTION OF AMIDES Public/Granted day:2009-06-25
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