Invention Grant
US07994357B2 Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
有权
用于抑制组蛋白脱乙酰酶的Cinamic化合物及其衍生物
- Patent Title: Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase
- Patent Title (中): 用于抑制组蛋白脱乙酰酶的Cinamic化合物及其衍生物
-
Application No.: US12418373Application Date: 2009-04-03
-
Publication No.: US07994357B2Publication Date: 2011-08-09
- Inventor: Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
- Applicant: Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
- Applicant Address: TW Taipei
- Assignee: Naturewise Biotech & Medicals Corporation
- Current Assignee: Naturewise Biotech & Medicals Corporation
- Current Assignee Address: TW Taipei
- Agency: WPAT, P.C.
- Agent Anthony King
- Main IPC: C07C303/00
- IPC: C07C303/00 ; C07C313/00 ; C07C259/04 ; C07D307/00
Abstract:
The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).
Public/Granted literature
- US20100256401A1 CINAMIC COMPOUNDS AND DERIVATIVES THEREFROM FOR THE INHIBITION OF HISTONE DEACETYLASE Public/Granted day:2010-10-07
Information query
