Apparatus and method for optimizing interpolation in the despreader data-path of a wireless telecommunications network employing Code Division Multiple Access (CDMA) technology. A base station dynamically evaluates its configuration to determine an interpolator location. The location of the interpolator in a despreader data-path is dynamically selected. A received signal is interpolated. The despread received signals are combined, and further processing is applied to the combined signal. To enhance system performance, the interpolator may, be located at least to perform chip-sample interpolation per antenna stream at chip rate, chip-sample interpolation per user at chip rate, or symbol-sample interpolation per user at sub-symbol rate.