Circuits and methods are disclosed for reducing interference from transmitter leakage in a radio transceiver. An exemplary method for reducing interference from transmitter leakage in a radio transceiver comprises downconverting, filtering, and sampling a radio frequency signal comprising a desired signal and a transmitter leakage signal to obtain a sampled signal of interest. The method further comprises generating a sampled distortion signal estimate that estimates one or more distortion products of the transmitter leakage signal, such as a squared amplitude obtained from a square-law device or corresponding digital function. Further, the method comprises dividing the sampled distortion signal estimate and the sampled signal of interest into a plurality of frequency channels. Finally, for a selected number of frequency channels, the method comprises combining the sampled distortion signal estimate for a frequency channel with the corresponding sampled signal of interest for the same frequency channel to obtain interference-reduced signal samples for the frequency channel.