Devices, systems, and methods for recording, and/or stimulation, and/or blocking of a nerve make use of a molded nerve cuff electrode. One or more electrodes are positioned in one or more frames within a casing. The exterior surface of the casing is wrapped in an insulating material, and the wrapped casing is positioned within a cover tube. One or more additional electrodes may be positioned anywhere outside of the casing. An applicator tool having a body to hold the molded nerve cuff in an expanded configuration is used to implant the cuff about a nerve.