A golf ball includes an inner core layer formed from a first rubber composition having a first Shore D hardness; an intermediate core layer formed from a second rubber composition; and a thermoplastic outer core layer having a second Shore D hardness. The outer core layer includes a copolymer of ethylene and an α,β-unsaturated carboxylic acid, an organic acid or salt thereof, and sufficient cation source to fully-neutralize the acid groups of the copolymer. An inner cover layer surrounds the multi-layer core and an outer cover layer is disposed about the inner cover layer. The inner core layer hardness differs from the outer core hardness by at least 10 points.