Invention Grant
US08007831B2 Loading of hydrophobic drugs into hydrophilic polymer delivery systems
有权
将疏水性药物加载到亲水性聚合物递送系统中
- Patent Title: Loading of hydrophobic drugs into hydrophilic polymer delivery systems
- Patent Title (中): 将疏水性药物加载到亲水性聚合物递送系统中
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Application No.: US12278827Application Date: 2007-02-09
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Publication No.: US08007831B2Publication Date: 2011-08-30
- Inventor: Andrew Lennard Lewis , Yiqing Tang , Maria Victoria Gonzalez Fajardo
- Applicant: Andrew Lennard Lewis , Yiqing Tang , Maria Victoria Gonzalez Fajardo
- Applicant Address: GB Surrey
- Assignee: Biocompatibles UK Limited
- Current Assignee: Biocompatibles UK Limited
- Current Assignee Address: GB Surrey
- Agency: Sughrue Mion, PLLC
- Priority: EP06250742 20060210
- International Application: PCT/JP2007/051299 WO 20070209
- International Announcement: WO2007/090897 WO 20070816
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K31/436 ; A61K31/337 ; A61K35/00 ; A61K31/573 ; A61K31/192 ; B01J13/04
Abstract:
A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
Public/Granted literature
- US20100166876A1 LOADING OF HYDROPHOBIC DRUGS INTO HYDROPHILIC POLYMER DELIVERY SYSTEMS Public/Granted day:2010-07-01
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