Invention Grant
- Patent Title: Methods to identify protein arginine deiminase 4 inhibitors
- Patent Title (中): 识别蛋白质精氨酸去酰亚胺酶4抑制剂的方法
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Application No.: US12262436Application Date: 2008-10-31
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Publication No.: US08007996B2Publication Date: 2011-08-30
- Inventor: Paul R. Thompson , Bryan Knuckley
- Applicant: Paul R. Thompson , Bryan Knuckley
- Applicant Address: US SC Columbia
- Assignee: University of South Carolina
- Current Assignee: University of South Carolina
- Current Assignee Address: US SC Columbia
- Agency: Dority & Manning, P.A.
- Main IPC: C12Q1/00
- IPC: C12Q1/00
Abstract:
In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.
Public/Granted literature
- US20090162877A1 Methods to Identify Protein Arginine Deiminase 4 Inhibitors Public/Granted day:2009-06-25
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