Invention Grant
US08008041B2 Site-specific incorporation of redox active amino acids into proteins
有权
将氧化还原活性氨基酸的位点特异性掺入蛋白质
- Patent Title: Site-specific incorporation of redox active amino acids into proteins
- Patent Title (中): 将氧化还原活性氨基酸的位点特异性掺入蛋白质
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Application No.: US10575991Application Date: 2004-10-13
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Publication No.: US08008041B2Publication Date: 2011-08-30
- Inventor: Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
- Applicant: Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine IP Law Group, P.C.
- Agent Gary Baker
- International Application: PCT/US2004/034089 WO 20041013
- International Announcement: WO2005/038002 WO 20050428
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C12N15/74 ; C07H21/04 ; C12P21/06
Abstract:
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
Public/Granted literature
- US20070009990A1 Site-specific incorporation of redox active amino acids into proteins Public/Granted day:2007-01-11
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