Invention Grant
US08008043B2 Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
有权
E1永生化细胞的培养物及其培养方法，从而提高产品的产率
- Patent Title: Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
- Patent Title (中): E1永生化细胞的培养物及其培养方法，从而提高产品的产率
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Application No.: US12804687Application Date: 2010-07-26
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Publication No.: US08008043B2Publication Date: 2011-08-30
- Inventor: Christopher A. Yallop
- Applicant: Christopher A. Yallop
- Applicant Address: NL Leiden
- Assignee: Crucell Holland B.V.
- Current Assignee: Crucell Holland B.V.
- Current Assignee Address: NL Leiden
- Agency: TraskBritt
- Priority: WOPCT/EP03/50155 20030509; WOPCT/EP03/50390 20030901; WOPCT/EP03/50940 20031204; WOPCT/EP2004/050061 20040130
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12P21/08 ; C12N5/02
Abstract:
Provided are processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, such as PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
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