Invention Grant
US08008266B2 Methods of treating cancer using immunostimulatory oligonucleotides
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使用免疫刺激性寡核苷酸治疗癌症的方法
- Patent Title: Methods of treating cancer using immunostimulatory oligonucleotides
- Patent Title (中): 使用免疫刺激性寡核苷酸治疗癌症的方法
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Application No.: US10719493Application Date: 2003-11-21
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Publication No.: US08008266B2Publication Date: 2011-08-30
- Inventor: Arthur M. Krieg , Alfred D. Steinberg , Dennis Klinman
- Applicant: Arthur M. Krieg , Alfred D. Steinberg , Dennis Klinman
- Applicant Address: US IA Iowa City US DC Washington US NY New York
- Assignee: University of Iowa Foundation,The United States of America as represented by the Department of Health and Human Services,Coley Pharmaceutical Group, Inc.
- Current Assignee: University of Iowa Foundation,The United States of America as represented by the Department of Health and Human Services,Coley Pharmaceutical Group, Inc.
- Current Assignee Address: US IA Iowa City US DC Washington US NY New York
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent Gregg C. Benson
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/00 ; C12N5/00 ; A61K48/00 ; C07H21/02 ; C07H21/04 ; C12P21/06
Abstract:
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
Public/Granted literature
- US20040087538A1 Methods of treating cancer using immunostimulatory oligonucleotides Public/Granted day:2004-05-06
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