Invention Grant
- Patent Title: Carbonyl reductase, gene therefor and use thereof
- Patent Title (中): 羰基还原酶，其基因及其用途
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Application No.: US11665065Application Date: 2005-10-20
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Publication No.: US08008461B2Publication Date: 2011-08-30
- Inventor: Noriyuki Kizaki , Makoto Ueda , Daisuke Moriyama , Naoaki Taoka , Yoshihiko Yasohara
- Applicant: Noriyuki Kizaki , Makoto Ueda , Daisuke Moriyama , Naoaki Taoka , Yoshihiko Yasohara
- Applicant Address: JP Osaka
- Assignee: Kaneka Corporation
- Current Assignee: Kaneka Corporation
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2004-312365 20041027
- International Application: PCT/JP2005/019269 WO 20051020
- International Announcement: WO2006/046455 WO 20060504
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N9/02 ; C12P21/02 ; C12P13/00 ; C07C255/01
Abstract:
The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the polypeptide and a transformant of producing the polypeptide. Another feature of the present invention is a process for producing an optically active alcohol such as (R)-3-hydroxy-3-phenylpropanenitrile by reducing a carbonyl compound such as 3-oxo-3-phenylpropanenitrile by use of the polypeptide or the transformant.
Public/Granted literature
- US20090029430A1 Novel Carbonyl Reductase, Gene Therefor and Use Thereof Public/Granted day:2009-01-29
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