Invention Grant
US08008472B2 RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
有权
使用短干扰核酸（siNA）的RNA干扰介导的人类免疫缺陷病毒（HIV）基因表达的抑制
- Patent Title: RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
- Patent Title (中): 使用短干扰核酸（siNA）的RNA干扰介导的人类免疫缺陷病毒（HIV）基因表达的抑制
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Application No.: US12777767Application Date: 2010-05-11
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Publication No.: US08008472B2Publication Date: 2011-08-30
- Inventor: James McSwiggen , Leonid Beigelman
- Applicant: James McSwiggen , Leonid Beigelman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/70 ; C12Q1/68
Abstract:
This invention relates to compounds, compositions, and methods useful for modulating human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of human immunodeficiency virus (HIV) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of HIV genes. The small nucleic acid molecules are useful in the treatment of HIV infection, AIDS, and/or disease and conditions related to HIV infection and/or AIDS in a subject or organism.
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