Invention Grant
- Patent Title: Metalloprotein inhibitors
- Patent Title (中): 金属蛋白抑制剂
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Application No.: US12722623Application Date: 2010-03-12
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Publication No.: US08008510B2Publication Date: 2011-08-30
- Inventor: David T. Puerta , Seth M. Cohen , Jana A. Lewis
- Applicant: David T. Puerta , Seth M. Cohen , Jana A. Lewis
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Schwegman, Lundberg & Woessner, P.A.
- Main IPC: C07D213/63
- IPC: C07D213/63 ; C07D315/00
Abstract:
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
Public/Granted literature
- US20100173952A1 METALLOPROTEIN INHIBITORS Public/Granted day:2010-07-08
Information query
