In a master-slave manipulator system, an intuitive operation can be achieved by a simple structure in which a layout of a monitor and an operation input device is not limited. A master-slave manipulator system is provided with a manipulator, a camera, a monitor, an operation input device, a manipulator controller and a master controller. The master controller is provided with an operation an information acquisition portion for operation command acquiring an operation reference data on the basis of the command by the operation input device, an acquirement information division portion dividing the operation reference data into a position movement reference data and an orientation reference data, and a moving direction compensation controller compensating the position movement reference data on the basis of the orientation reference data so as to output a position moving command compensation information. The manipulator controller controls the position and orientation of the manipulator on the basis of the position moving command compensation information and the orientation reference data.