A technique for agile region and band conscious frequency planning for wireless transceivers in which a comparison frequency is selected for generating a local oscillator signal. The comparison frequency (Fcomp) is selected for a frequency band of a particular communication standard or protocol, in order not to introduce harmonic components of the selected comparison frequency in a transmitted signal from the wireless device that generates spurious emissions restricted by the particular communication protocol or another protocol. The Fcomp selection may also take into consideration restrictive region-specific criteria for out-of band spurious emissions.