A distributed antenna system comprises a base transceiver station, a plurality of distributed antenna units and a signal routing apparatus. The base transceiver station has a plurality of output ports that generate a plurality of downlink signals having overlapping transmit frequencies and containing different communication content. The different communication content is directed toward each of a plurality of mobile units. The base transceiver station also has at least one uplink receive port that receives an uplink signal. The uplink signal includes communication content received from at least one of the mobile units. The plurality of distributed antenna units have coverage areas that are non-overlapping or only partially overlapping. The signal routing apparatus routes the downlink signals to the plurality of distributed antennas such that each of the plurality of downlink signals are transmitted by one or more of the distributed antennas and each distributed antenna only transmits one of the downlink signals.